SPINE MRI AND ELECTROPHYSIOLOGY METHODS IN THE MONITORING OF THE DISEASE COURSE IN ACUTE INFLAMMATORY DEMYELINATING POLYNEUROPATHY

Voitenkov V.B., Marchenko N.V., SkrichenkoN.V.
Pediatric Research and Clinical Center for Infectious Diseases, St-Petersburg, Russia

Our aim was to establish usefulness of MR-tractography and fractional anisotropy on monitoring course of the disease in acute inflammatory demyelinating polineuropathy (AIDP) in children. Methods. 6 chidren (4males, 2 females, average age 14,6±0,5 years, range 12-16 years) with established AIDP were included in our study. AIDP was established by the typical clinical course of the disease and electrophysiology data (conduction studies of the peripheral nerves and diagnostic transcranial magnetic stimulation) according to Hadden criteria. All patients underwent MRI of the spine with tractography and fractional anisotropy (FA) twice during the course of the disease - once on its early stage (5-7 days) and once on the early recovery stage (30-35-th day since the symptoms onset). Results. On the first measure FA values were 0.7±0.04 and on the second were 0.51±0.07. On tractography decrease of consistense motor pathways were seen. TMS parameters also demonstrated lengthening of the motor evoked potentials latencies (24.19±3.21 ms at the first and 37.93±2.17 ms at the second measure). Conclusions. MRI-tractography and fractional anisotropy were effective in the evaluation of the central nervous system involvement in children with AIDP. During the course of the disease, significant lesions of the motor pathways on the central level, established by the combination of electrophysiology (TMS) & neuroradiology (MRI), was registered. These methods should be more often implemented in the diagnostics of these inflammatory disorders in children.
 

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